Participants were instructed to always keep the beer glass on the table except when taking a sip. The scale was connected to a computer in an adjacent room that ran a customized program that sampled the scale at 5 Hz and detected any weight changes that exceeded 1 gm. Additional details and photos of the device can be found in Lukas et al. . Participants were randomized on a blind basis to receive either 4 capsules of the extract or placebo 2.5 hours before the start of an afternoon drinking session. This pretreatment time was selected based on our pharmacokinetic study of puerarin absorption and elimination (Penetar et al., 2006). A standardized formulation of kudzu extract produced minimal side effects, was well-tolerated, and resulted in a modest reduction in alcohol consumption in young nontreatment-seeking heavy drinkers. While kudzu root has a long history in traditional Chinese medicine, people most often use it to help treat alcohol dependence.
Now kudzu’s popularity is also picking up in the Western world as a wellness supplement. Kudzu root comes from a trailing vine that often grows over other plants. Subjects cannot be actively seeking treatment for any drug or alcohol dependence. Changes in the chemistry of 6″-malonyl-7′-β-glucosyldaidzein, a major soybean component, during food processing. Dry heating of 6″-malonyl-7′-β-glucosyldaidzein leads to decarboxylation to 6″-acetyl-7′-β-glucosyldaidzein . Heated, aqueous extraction of soybeans to make soy milk and tofu, removes the malonyl group to make daidzin . Fermentation can also lead to hydrolysis of the glucosyl group . Is one of the earliest medicinal plants used in traditional Chinese medicine. It has many profound pharmacological actions, including antidipsotropic activity. There is information that suggests kudzu contains ingredients that counteract alcohol.
A Phytoestrogen Puerarin and Its Health Effects
One limitation of this study is the lack of a dose-response assessment. The complete lack of side effects would favor the conduct of such studies. Other limitations of the present study are the use of a rather narrow aged male population who drink only at moderate levels. The present study provides further evidence that extracts of the kudzu root are effective in reducing alcohol consumption but unlike any other medication it does so after a single dose was taken shortly before a binge drinking opportunity. And, contrary to disulfiram treatment, the drinking that did occur after kudzu administration did not result in any noxious side effects, increases in subjective ratings of nausea, uncomfortable, or feeling terrible. The reduction in drinking was evident rather quickly as it was apparent kudzu extract for alcoholism for the second through sixth beers and no kudzu-treated participant drank five or six beers, which suggests that binge drinking was curtailed. Our laboratory has been involved in assessing an extract of the kudzu root for its ability to reduce alcohol consumption in humans. In the first, kudzu extract was administered for 7 days and acute binge drinking was suppressed (Lukas et al., 2005). In the second, participants who were treated for 4 weeks with kudzu extract significantly reduced their alcohol consumption during weeks 2 through 4 of the study (Lukas et al., 2013). We have subsequently shown that puerarin is the major active isoflavone because 7 days treatment with this compound alone (1,200 mg/day) produced a similar reduction of binge drinking as the extract (Penetar et al., 2012).
Declinol utilizes a proprietary and patent-pending encapsulation technology that enhances the absorption and bio-availability of its herbal compounds. The active ingredients are all encapsulated, or enveloped, using specific processing techniques, within phosphatidyl choline based spheres that act as transport vehicles. The process mimics natural actions that take place within the gut to enable proper absorption of nutrients, especially phyto-nutrients and fat soluble vitamins. The body’s own process in this regard creates micelles, single layer or unilamellar spheres in the size range of approximately 100 nanometers that typically can transport single nutrients. However due to dietary and physiological inefficiency, this process can often be hampered. The technology utilized with Declinol creates multi-layer or multi-lamellar spheres that are readily available and can transport multiple nutrients simultaneously. The nature of these spheres, possessing several layers, also allows both fat and water soluble nutrients to be combined in the same sphere. Recently, unique discoveries have been made pertaining to the actions of bitters, and a family of 30 specific bitter flavor receptors in the GI Tract. Known as TAS2R’s, these receptors are located throughout the gut and are set to detect a variety of differing bitter profiles. When stimulated, TAS2R receptors elicit a number of actions.
PLANT DISEASES CAUSED BY PARASITIC HIGHER PLANTS, INVASIVE CLIMBING PLANTS, AND PARASITIC GREEN ALGAE
Even a tiny amount of alcohol can cause violent illness while on these drugs. By contrast, kudzu creates a mild flushed feeling at most and leaves the drinker craving alcohol a bit less. As expected, I didn’t really feel anything after taking kudzu until I began drinking. I recall feeling a very slight prickly feeling in my skin after I’d had a few drinks, and a mild head rush. I did not feel more drunk than usual, but I definitely drank less.
- Here are our best tips to find the perf kudzu root supplement.
- Kudzu roots can be dried and ground into a powder, which some people use as breading for fried foods or as a thickener for soups and sauces.
- So lowering the levels of that brain chemical dopamine should help control an alcoholic’s cravings.
- In its raw form, kudzu root resembles other root tubers, such as potatoes or yams.
- The technology utilized with Declinol creates multi-layer or multi-lamellar spheres that are readily available and can transport multiple nutrients simultaneously.
Kudzu is thought to increase blood flow throughout the body. When alcohol is consumed, kudzu may reduce the time it takes for it to travel to the brain. A slightly increased concentration of alcohol in the brain results in a quicker reward, which in turn reduces a person’s desire to drink more alcohol. One of the herbals in Declincol, Gentian, is considered the king of the bitter herbs.
Eucalyptus oil is known to have herbicidal, antifungal, and antimicrobial properties. Here are the top potential benefits of using eucalyptus oil. Botanicals and their bioactive phytochemicals for women’s health. Other research suggests that kudzu supplements may also play a role in preventing migraine attacks. These are exciting findings, but much more research is needed before we can be sure. This clinically tested formula acts by cooling down Heat with Lian Qiao, Chai Hu, Ge Gen and Gan Cao. It also cools the Blood with Sheng Di and Chi Shao, amplified by the Blood invigorating medicinals Dang Gui, Tao Ren and Hong Hua.
After that, each subject was given the pill he or she didn’t get the first time and told to take it for a week. Each then returned for a fourth and final drinking session. An extract of the Chinese herb kudzu dramatically reduces drinking and may be useful in the treatment of alcoholism and curbing binge drinking, according to a new study by McLean Hospital and Harvard Medical School researchers. Potential health perks of taking kudzu root include decreasing alcohol intake, easing menopause symptoms, and regulating blood sugar levels. This treatment increased the activity of the antioxidant enzymes Cu/Zn SOD and catalase, and attenuated the hepatic oxidative damage in rats exposed to ethanol.
Clinical & Medical Journals
Taking kudzu along with medications that also slow clotting might increase the chances of bruising and bleeding. In Chinese pharmacy books, kudzu is listed as a possible treatment for alcohol-related hangovers and cravings, Penetar tells WebMD. Bouchery EE, Harwood HJ, Sacks JJ, Simon CJ, Brewer RD. Economic costs of excessive alcohol consumption in the U.S., 2006. A. Policosanol is a natural compound derived from sugar-cane wax, beeswax or yams. While it might not lower cholesterol as well as statin-type medicines, data suggest it can lower bad LDL cholesterol and even raise good HDL cholesterol. “Apparently, this effect is sufficient to delay or eliminate the desire to drink subsequent beers,” he adds. The study team should get back to you in a few business days. And those cravings are rooted in a specific part of the brain that’s activated whenever we feel pleasure. Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism.
While the drinking pattern changed in kudzu users, the drinkers reported no change in their desire to drink when they began each session. Participants who took the extract in earlier studies said they felt more “tired,” “floating” and “intoxicated” after one drink, suggesting that kudzu “may be prolonging or enhancing the acute effects of the first drink,” Lukas says. NPI-028 and one of its pure components, NPI-031G, selectively reduced alcohol intake in alcohol-preferring Sober House rats and significantly reduced ethanol intake in FH rats without affecting food or water intake. This combination of Kudzu plants and extracts and Radix Bupleuri in the Declinol formula significantly reduced Alcohol Use Disorders Identification Test scores administered to ten heavy drinkers attending a recovery program. In 2012, I ordered some high quality organic kudzu capsules after reading about the potential for kudzu to curb alcohol consumption.
You may also be interested in: Herbal Remedies and Acupuncture for Addiction Recovery
Throughout the gut and endocrine system, digestive secretions are promoted in the stomach, pancreas, gall bladder, liver, and small and large intestine. Digestion, assimilation, and elimination are all improved. Bitters have been used to help relief symptoms of constipation, flatulence, appetite loss, vomiting, heartburn, abdominal pain and nausea . For centuries, ginseng has been used in traditional Chinese medicine. Kudzu root is the edible root of the Pueraria genus of plants. The kudzu plant is a vine that resembles poison ivy and is native to several Asian countries. Some research specifically on the kudzu species Pueraria mirifica suggests that doses of 50–100 mg per day appear to have a low risk of adverse side effects . In its raw form, kudzu root resembles other root tubers, such as potatoes or yams. “The most urgent need is helping people who cannot help themselves, who need a drug to help them stop drinking,” Keung said.
What plants make what alcohol?
A dizzying array of plants has been converted into alcohol over the ages, everything from agave (tequila) to yams (beer and vodka). Many plants are used primarily as garnishes, such as spearmint (mint julep), olives (martini) and cherries (Manhattan).
Kudzu vine is now widely distributed in the United States, including all the southeast, north to Massachusetts and Illinois, and west to Texas and Oklahoma. Approximately 2,000,000 acres of forest land are covered by Kudzu vine. Development of a recognized, validated testing method and threshold equol value or equol-to-daidzein ratio will aid future interpretation of evidence. The plant Cytisus laburnum from which cytisine is derived is traditionally used as an emetic and purgative, so nausea and vomiting is the main side effect. Like verenicline, it can disrupt the sleep cycle and cause nightmares. Kudzu might decrease how fast the body gets rid of methotrexate .
Kudzu herb extract could be a new treatment for alcoholism http://t.co/kUPeUW69
— Kaunda Chama (@therealkaunda) May 22, 2012
He operates a private practice in Santa Monica, California. Verywell Health’s content is for informational and educational purposes only. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Get FREE daily coaching messages from Chris Scott to help you quit or cut down on alcohol in just 10 days. In my opinion, the Planetary Herbals brand is a great option for someone who has not yet quit drinking, and who wants to try pure kudzu powder on its own.
What is a natural alcohol?
Substances such as cholesterol, found in most animal tissues (and abundant in egg yolks), and retinol (vitamin A alcohol), extracted from fish liver oils, are examples of naturally occurring sources of alcohols.
Kudzu root, also called Japanese arrowroot, is native to China, Japan, and Korea. Today, kudzu grows in other parts of the world as well, including in the southern United States. None of the subjects had any side effects from mixing kudzu with beer. After the first session, some subjects received capsules of kudzu, others a placebo. Red root has been touted as a treatment for things from respiratory issues to UTIs.
There is some evidence that kudzu root dietary supplements may cause liver injury. One study in mice found that taking 10 mg per day of kudzu root extract for 4 weeks caused liver toxicity . One small study looked at the effects of kudzu in 17 men ages 21–33 who reported drinking approximately 22–35 drinks per week. The researchers gave participants either kudzu extract or a placebo every day for 4 weeks . The ability of puerarin and related isoflavones to facilitate alcohol’s entry into the brain has not been systematically studied. For this mechanism to be plausible, the more rapid penetration of alcohol into the brain would have to trigger a satiety mechanism rather quickly such that the desire for the next drink is delayed—thus interrupting a binge episode. This is precisely what was observed in the present study as kudzu’s effects were evident after a single dose within a few hours of administration. Of course, it is entirely possible that any of the above mechanisms may also develop with repeated administration and complement the immediate altered absorption effect that likely explains kudzu’s rapid onset of action. Drinking was recorded using a custom built end table that contained a digital scale beneath a ceramic tile insert in the tabletop (Ohaus model #B10P with I5S controller).
Kudzu herb extract could be a new treatment for alcoholism – http://t.co/GRQL3jzX http://t.co/rZdrahWA
— StoriesOfRedemption (@wegotashot) May 21, 2012